Lobular breast tumor

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Invasive lobular carcinoma ILCsometimes called infiltrating lobular carcinoma, is the second most common type of breast cancer after invasive ductal carcinoma cancer that begins in the milk-carrying ducts and spreads beyond it. According to the American Cancer Society, more thanwomen in the United States find out they have invasive breast cancer each year. Lobular means that the cancer began in the milk-producing lobules, which empty out into the ducts that carry milk to the nipple.

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Breast cancer is classified into different types based on how the cells look under a microscope. Most breast cancers are carcinomas, a type of cancer that begins in the linings of most organs. Ductal carcinoma in situ DCIS is characterized by cancerous cells that are confined to the lining of the milk ducts and have not spread through the duct walls into surrounding breast tissue.

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The first time Leigh Pate heard the term was when she got a phone call from her doctor following a series of diagnostic tests. By the end of her treatment and recovery, she not only knew what lobular breast cancer was, she was determined to shine a spotlight on this idiosyncratic subtype. But lobular presents differently, it behaves differently and it has different subtypes and variants.

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When your breast was biopsied, the samples taken were studied under the microscope by a specialized doctor with many years of training called a pathologist. The pathologist sends your doctor a report that gives a diagnosis for each sample taken. Information in this report will be used to help manage your care.

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What is invasive lobular breast cancer? What are the symptoms of invasive lobular breast cancer? How is invasive lobular breast cancer diagnosed?

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Invasive lobular and ductal carcinomas differ with respect to risk factors. Invasive lobular carcinoma is more strongly associated with exposure to female hormones, and therefore its incidence is more subject to variation. Similarly, invasive lobular carcinoma is more strongly associated with early menarche, late menopause and late age at first birth.

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All breast cancers initially form inside the milk duct near the area where the duct meets the milk gland, or lobule — a structure called the terminal duct lobular unit. As long as the abnormal cells remain inside the milk duct they are known as carcinoma in situ. When they break out of the milk duct and get into the fatty tissue of the breast, they become invasive breast cancers.

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Tumours are generally of a good prognostic phenotype, being low histological grade and low mitotic index, hormone receptor positive and HER2, p53 and basal marker negative, and with a generally good response to endocrine therapy. Despite this, clinicians face countless challenges in the diagnosis and long-term management of patients, as they encounter a tumour that can be difficult to detect through screening, elicits a very invasive nature, a propensity for widespread metastatic colonisation and, consequently, in some studies a worse long-term poor outcome compared with invasive carcinoma of no special type. Here we review the morphological and molecular features that underpin the disparate biological and clinical characteristics of this fascinating tumour type.

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Lobular breast cancer, also called invasive lobular carcinoma ILCoccurs in the breast lobes or lobules. Lobules are the areas of the breast that produce milk. ILC is the second most common type of breast cancer.

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Invasive Lobular Carcinoma ILCalso known as infiltrating lobular carcinoma, is the second most common form of breast cancer diagnosed in the United States, representing percent of diagnosed invasive breast cancers. This type of cancer is more difficult to see on imaging because of the way the cells stream through the breast tissue. Invasive lobular carcinomas are usually larger than expected from the mammogram.

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