Hysterectomy as breast cancer prophylaxis

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One-quarter of patients with breast cancer are diagnosed at a premenopausal age and these young women may be directed to discuss oophorectomy with their ob. Ovarian ablation has been associated with improved overall survival and disease-free survival among these patients. Estrogen is an important promoter of breast cancer and is predominantly derived from ovarian tissue in premenopausal women.

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It is well possible that patients diagnosed with breast cancer have been undertreated in the past. As gynaecological oncologists we regularly see patients with uterine and ovarian cancer who had breast cancer in the past. Some of those poor breast cancer women even had a hysterectomy and had their ovaries preserved.

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Many women who are considered high-risk for breast cancer also have a much higher-than-average risk of developing ovarian cancer. If after meeting with a counselor you are found to be at high risk for developing breast and ovarian cancer, you may want to explore different strategies for reducing your risk. Although prophylactic ovary removal can significantly reduce the risk of developing ovarian cancer — and also reduce the risk of breast cancer when done before menopause — this surgery is a serious choice that can have a considerable impact on your life.

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Can a woman have risk-reducing surgery if she has already been diagnosed with breast cancer? What are the cancer risk reduction options for women who are at increased risk of breast cancer but not at the highest risk? Two kinds of surgery can be performed to reduce the risk of breast cancer in a woman who has never been diagnosed with breast cancer but is known to be at very high risk of the disease.

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By Charlotte Bath December 1, Advertisement. The decision to have a concurrent hysterectomy should be individualized, Dr. Kauff stressed, and based on a careful appraisal of the risks and benefits of also removing the uterus.

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In premenopausal women, most of the estrogen in the body is made by the ovaries. Because estrogen makes hormone-receptor-positive breast cancers grow, reducing the amount of estrogen in the body or blocking its action can help shrink hormone-receptor-positive breast cancers and reduce the risk of hormone-receptor-positive breast cancers coming back recurring. This is called prophylactic or protective ovary removal, or prophylactic oophorectomy.

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Our cancer specialists at Penn Medicine's Abramson Cancer Center believe that knowing the risks for ovarian cancer is one of the best ways to maintain gynecologic health. How you understand and translate health risks impacts your decision-making when it comes to treatment options. At Penn Medicine's Abramson Cancer Center, we are national leaders in the field of breast and ovarian cancer genetics.

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Georgia Hurst is a patient advocate for those with Lynch syndrome. She has the MLH1 mutation and fortunately has never had any cancer. She is the co-creator of GenCSM Genetic Cancer Social Media on Twitter, and her advocacy work has afforded her opportunities to write for medical journals, various websites and genetic testing companies, as well as collaborate as a stakeholder for the National Academy of Sciences: Genomics and Population Health Collaborative. Her loves include: her son, her dog, books, photography, long walks in the woods, and seeking out fungi after the rain.

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Tamoxifen use is associated with an increased risk of potentially serious adverse events, principally endometrial cancer and venous thromboembolic events and, therefore, detailed knowledge of the effects of tamoxifen is important. With more cases of breast cancer being found as the follow-up time increases, it is now possible to perform more detailed analysis of the Italian Randomized Trial of Tamoxifen. After a median of

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