In some cases, tumours can fight back, adapting to become resistant to the immune response. Certain cancers, including bowel, pancreatic, ovarian and breast, produce a molecule called gamma-aminobutyric acid — or GABA for short. GABA is better known for its role as a neurotransmitter, and is important for communication within the nervous system.
Despite the detection and treatment of breast cancer that can lead to years of remission, breast cancer cells often still find a way of escaping into the brain to eventually grow new tumors. Looking into why the brain is increasingly becoming the first site of recurrence after the treatment of advanced breast cancer — despite other areas of the body being in remission — a team of researchers found that breast cancer cells are like chameleons by taking on brain characteristics to survive. In this hard-fought life extension, brain metastases are being unmasked as the next battleground for extending the lives of women with breast cancer.
Skip to search form Skip to main content. The aim of the study was to evaluate the level of GABA in breast cancer, in relation to clinical and epidemiological data. GABA level was assessed using spectrofluorometric method in tumour homogenates.
By Alyssa Botelho. Women with breast cancer often enjoy several years in remission, only to then be given the devastating news that they have developed brain tumours. For every tumour that originates in the brain, 10 arrive there from other organ systems.
Correspondence Address: Prof. Hildegard M. E-mail: hmsch utk.
This is an open access article distributed under the terms of Creative Commons Attribution License. The GABA A receptor is a heteropentamer, consisting of five subunits that form a chloride ion channel. In addition, due to its upregulation in the human endometrium during the window of implantation, GABRP may play an important role in the generation of a receptive endometrium 5.
High-grade chondrosarcoma, which has a high incidence of local recurrence and pulmonary metastasis despite surgical resection, is associated with poor prognosis. Therefore, new and effective adjuvant therapies are urgently required for this disease. Gamma-aminobutyric acid GABAwhich acts as a neurotrophic factor during nervous system development, is related to the proliferation and migration of certain cancer cells.
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Breast cancer is a heterogeneous disease comprised of distinct subtypes predictive of patient outcome. Tumors of the basal-like subtype have a poor prognosis due to inherent aggressiveness and the lack of targeted therapeutics. Continued evaluation of basal-like breast cancer BLBC biology is essential to identify novel therapeutic targets. GABRP is a component of a cell surface receptor, thus, these findings suggest that targeting this new signaling axis may have therapeutic potential in BLBC.