Breast cancer responsive to estrogen

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Hormonal therapy, sometimes also called anti-estrogen therapy, works by lowering the amount of estrogen in the body or blocking estrogen from attaching to the breast cancer cells. You and your doctor will work together to decide which form of hormonal therapy is best in your situation. Topics you may discuss include: other features of the breast cancer, such as stage; other medical conditions you may have; whether or not you have been through menopause menstrual periods have stopped ; and your personal preferences.

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Hormones are substances that function as chemical messengers in the body. They affect the actions of cells and tissues at various locations in the body, often reaching their targets through the bloodstream. The hormones estrogen and progesterone are produced by the ovaries in premenopausal women and by some other tissues, including fat and skin, in both premenopausal and postmenopausal women and men.

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Oxidative stress can modify estrogen receptor ER structure and function, including induction of progesterone receptor PRaltering the biology and clinical behavior of endocrine responsive ER-positive breast cancer. To explore the association of these signatures with breast cancer biology, microarray data were analyzed from ER-positive primary human breast cancers pooled from three independent studies. Endocrine therapy, in turn, can alter tumor expression of ER and PR [ 56 ]; in particular, upon acquiring resistance to an endocrine agent such as tamoxifen, metastatic breast cancers usually retain ER expression [ 5 ] but frequently exhibit loss of PR expression [ 6 ].

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Context: Breast cancer is the most common cancer in women worldwide. Estrogen receptor ER positive breast cancer constitutes the majority of these cancers. Hormone therapy has significantly improved clinical outcomes for early- and late-stage hormone receptor positive breast cancer.

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Estrogen receptor-positive ER-positive breast cancer is the most common type of breast cancer diagnosed today. According to the American Cancer Societyabout 2 out of every 3 cases of breast cancer are hormone receptor-positive. Most of these cases are ER-positive, meaning that there are estrogen receptors on the surface of the cell that bind to estrogen.

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The model hypothesis highlights DERE axes as hot spots for concomitant and aberrant genome amplification in luminal breast cancer; thus coordinately and persistently deregulating target transcriptome, including co-amplification of oncogenes and repression of tumor-suppressor loci for cancer development and endocrine therapy resistance. Moreover, integration of 3C dataset with published time-course study of gene expression revealed 95 loci remotely interacting with 20q13 DEREs, 38 genes with 17q23 DEREs, and 46 estrogen-responsive targets [ 5 ]. It is reasonable to speculate that the increased frequency of chromatin interactions might play a role to elicit epigenetic repression of DERE-regulated genes.

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Not all breast cancers are the same. Understand what type of breast cancer you have and how it differs from other types of breast cancer. Once you've been diagnosed with breast cancer, your doctor will review your pathology report and the results of any imaging tests to understand the specifics of your tumor. Using a tissue sample from your breast biopsy or using your tumor if you've already undergone surgery, your medical team determines your breast cancer type.

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Wrote the paper: AA JL. Advice and suggestions: BAR. Estrogen signaling plays a critical role in the pathogenesis of breast cancer.

Breast cancer is the most common type of cancer worldwide. Moreover, when the estrogen receptor binds to the DNA in the nucleus of a cell, it activates nearby genes causing the tumor cells to grow and divide. Learning more about how cancer cells respond to estrogen is very important.


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